Donor Surfactant Protein D (SP-D) Polymorphisms Are Associated With Lung Transplant Outcome
نویسندگان
چکیده
منابع مشابه
Common Genetic Variants of Surfactant Protein-D (SP-D) Are Associated with Type 2 Diabetes
CONTEXT Surfactant protein-D (SP-D) is a primordial component of the innate immune system intrinsically linked to metabolic pathways. We aimed to study the association of single nucleotide polymorphisms (SNPs) affecting SP-D with insulin resistance and type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We evaluated a common genetic variant located in the SP-D coding region (rs721917, Met(31)T...
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Lung surfactant is a complex mixture of lipids and proteins, which is secreted from the alveolar type II epithelial cell and coats the surface of alveoli as a thin layer. It plays a crucial role in the prevention of alveolar collapse through its ability to reduce surface tension. Under normal conditions, surfactant homeostasis is maintained by balancing its release and the uptake by the type II...
متن کاملPolymorphisms within Exon 9, But Not Intron 8, of the Vitamin D Receptor Gene Are Associated with Asthma
Objective(s) Deregulation of the immune system through allied factors and cytokine responses are thought to be important contributors to the pathogenesis of asthma. Vitamin D3 and its nuclear receptor appear to be factors that maybe involved in regulating immune responses during the progression of asthma. The aim of this study was to investigate the association between polymorphisms in intron ...
متن کاملSerum levels of surfactant protein D are increased in mice with lung tumors.
Most murine lung tumors are composed of differentiated epithelial cells. We have reported previously that surfactant protein (SP)-D is expressed in urethane-induced tumors. Serum levels of SP-D are increased in patients with interstitial lung disease and acute respiratory distress syndrome and in rats with acute lung injury but have not been measured in mice. In this study, we sought to determi...
متن کاملSurfactant Protein D, a Marker of Lung Innate Immunity, Is Positively Associated With Insulin Sensitivity
OBJECTIVE Impaired lung function and innate immunity have both attracted growing interest as a potentially novel risk factor for glucose intolerance, insulin resistance, and type 2 diabetes. We aimed to evaluate whether surfactant protein D (SP-D), a lung-derived innate immune protein, was behind these associations. RESEARCH DESIGN AND METHODS Serum SP-D was evaluated in four different cohort...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2013
ISSN: 1600-6135
DOI: 10.1111/ajt.12326